CLINICAL RESULTS OF FIBROBLAST ACTIVATION PROTEIN (FAP) SPECIFIC PET FOR NON-MALIGNANT INDICATIONS: SYSTEMATIC REVIEW

Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review

Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review

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Abstract Purpose Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018.While most of the existing literature has been focussed on the application of FAP-specific PET in various kinds of cancers, some researchers have, both intentionally or unintentionally, used FAP-specific PET in patients with non-cancerous diseases.The purpose of this systematic review is therefore to summarize the available evidence of FAP-specific PET for non-malignant indications.Methods The MEDLINE database was searched for studies presenting the clinical use of FAP-specific PET, the records were harry potter magsafe case screened according to PRISMA guidelines and articles containing patients suffering from non-malignant diseases were included.

Results Sixteen studies with here 303 patients were included.FAP-specific PET has been used in cardiac imaging, IgG4-related disease, benign tumors as well as various kinds of inflammation.Two prospective studies on FAP-specific PET for IgG4-related disease show its potential to differentiate inflammatory from fibrotic lesions, which could be used to determine the management of these patients.Conclusion While publications on FAP-specific PET for non-malignant indications are mostly limited to case reports and incidental findings, the first retrospective and prospective studies present promising results for IgG4-related as well as cardiovascular disease that warrant further research.

Several currently recruiting trials will add to the body evidence in the next few years.

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